Mitochondrial renewal
Researchers measured increases in proteins associated with mitochondrial recycling in muscle tissue.
Study illustration supplied by Timeline. See methods and limitations.
Read the published study1
Mitopure SoftgelsUrolithin A
Improve your cellular health by taking Mitopure in its simplest form with two vegan softgels daily for the recommended dose of Urolithin A (500mg of Mitopure). Each sachet contains 60 softgels, which will last you a month.†
Key ingredients
Urolithin A
Highly pure Urolithin A clinically-validated and proven to target essential root causes of aging.
Clean formulation:
- Vegan
- Non-GMO
- Gluten free
- Free of big 8 food allergens
- Lactose free
How to use
Take two vegan softgels daily for the recommended dose of Urolithin A (500mg of Mitopure).
Mitopure SoftgelsBuy 1, Get 1 Free
Compare us to other
The Ultimate Longevity Powerhouse
Swipe to compare all columns →
| Comparison criteria |  Mitopure |  NAD+ |  CoQ10 |  Creatine |  Spermidine |
|---|---|---|---|---|---|
| Directly activates mitophagy | ✓ | × | × | × | Partial |
| Targets a root cause of age-related cellular energy decline | ✓ | Partial | Partial | × | Partial |
| Benefits without changing exercise routine | ✓ | ✓ | ✓ | × | ✓ |
| Complete human clinical trials | ✓ | Limited | ✓ | ✓ | Limited |
The Original Urolithin A Supplement
Swipe to compare all columns →
| Comparison criteria | Mitopure |  Other Urolithin A |
|---|---|---|
| 5 Gold Standard Clinical Trials | ✓ | × |
| #1 Doctor-Recommended Brand | ✓ | × |
| NSF Certified | ✓ | × |
| Exceptional purity | ✓ | Unknown |
| Patented Urolithin A | ✓ | × |
Brand-provided comparison from Timeline. This is not an independent head-to-head trial.
Clinical research
The science behind Mitopure
Muscle strength
A four-month randomized trial in 88 adults aged 40–64 studied 500 mg and 1,000 mg daily. Some muscle-strength measures improved; the primary peak-power endpoint did not significantly improve.
Study illustration supplied by Timeline. See methods and limitations.
Read the published study
Cellular energy
A clinical study assessed safety, exposure and mitochondrial biomarkers in sedentary older adults. Biomarker changes are not a guaranteed feeling of increased energy.
Study illustration supplied by Timeline.
Read the published study
Urolithin A in the bloodstream
A crossover trial in 100 adults compared a food product containing 500 mg Urolithin A with pomegranate juice. Researchers measured blood exposure; this was not a head-to-head efficacy trial of these softgels.
Study illustration supplied by Timeline.
Read the published study
Your cells feel the benefits before you do
Illustrative timeline described by Timeline. Individual outcomes and timing may vary.
Urolithin A gets absorbed
You've just begun taking Mitopure and it's already springing into action. Urolithin A levels peak in your bloodstream, targeting key organs like your muscles.
Cellular recycling is activated
Mitopure® stimulates mitophagy, a potent recycling and cleansing mechanism that rejuvenates the mitochondria, the energy factories in your cells.
New healthy mitochondria
One month in, your cells are transforming. Damaged mitochondria are removed and healthier ones are produced in a process called mitochondrial biogenesis.
Enhanced cellular renewal
With our mitochondria recharged and renewed, the cells throughout your body are starting to function optimally.
Increased muscle strength*
Four months in, your muscle cells are reenergized and you’re getting stronger — even without a change in your exercise routine.1
Research continues
Clinical trials on additional long-term, system-wide benefits of Mitopure are currently underway.
Rigorous quality standards
Product quality matters. Explore the independent certification listings for Timeline Mitopure and the ingredient documentation for Urolithin A.
Timeline Vegan Softgels appear on the Clean Label Project product certificate.
Timeline Mitopure Softgels appear in the NSF Certified for Sport product directory. The listing identifies certified lots.
FDA recorded “no questions” for Amazentis’s GRAS notice 791 covering specified food uses of Urolithin A. This is not FDA approval of this finished supplement.
In the press
Press quotations presented on Timeline’s product page.
“Mitopure: your body’s very own power plant.”
Source: Timeline
“Research shows ‘powerful and measurable’ effects in combating muscle weakening.”
Source: Timeline
“Anti-aging science is littered with promising results [...] but Urolithin A seems different.”
Source: Timeline
“To push your training to new heights, you want to think about nutrition at the microscopic level.”
Source: Timeline
“Gut microbiome may hold key to combat muscle decline in aging.”
Source: TimelineCUSTOMER EXPERIENCES
Customer experiences
17 reviews displayed on Timeline’s product page, collected October 18, 2026. These are brand-product reviews, not purchases verified by this store. Individual experiences vary.
Helps with mental and physical energy!
I have used Mitopure for almost three years and feel it has contributed directly to my excellent energy and good health. At 57 I teach fitness classes, play tennis, lift heavy weights, and lead an active, fun life. I'm hoping Mitopure is helping my mitochondria function the best they can, both now and for many years to come!
no changing
didn’t see any of those benefits mentioned by the company, and the return isn’t as straightforward as they make it sound.
Everyone Needs This
Mitopure is a particularly pure form of Urolithin A, clinically proven to increase muscular strength, initiate autopphagy, and ward off age related mental decline. This is an awesome product that everyone should probably be taking, but certainly anyone over the age of 50.
Endurance, strength and mental clairity
This is a great addition to my longevity routine. I actually noticed within a week an improvement in recall and my energy level is consistant during a workout. Not to mention the increase I feel in muscular strength.
More energy
I have been taking the supplement for over six months and noticed such a difference in feeling sluggish and brain fog
Great mitochondrial support and an unexpected surprise of an increased libido!
I have noticed a remarkable improvement in my energy and stamina. In addition I'm doing the other nutritional choices and lifestyle changes necessary. One other effect or side effect is a tremendous boost to my libido! I did not expect this. Forget about the other products out there for this. Everyone should be taking this product to power up our mitochondrial support! Very happy with this product!
The gel tabs are...
The gel tabs are easy to swallow.
Seeing the benefits !!
I heard about Mitopure on two of my favorite podcasts. I already take a zillion supplements, but this one sounded different. I have an autoimmune condition and have been feeling just a little droopy lately, so figured Mitopure was worth a try. I didn’t expect to get results so quickly— within the first week, I was feeling more energized. I’m now two full months in, and I am definitely seeing results. I didn’t change anything else in my diet or supplement stack—so the results must be attributed to Mitopure! Way too coincidental to be placebo. A few of my psoriasis plaques have vanished! I have even noticed visible adipose tissue loss. Perhaps my issue has been my mitochondria all along. Thanks guys!
Je ne sais plus exactement , peut-être plus d'un an ?
Depuis que je prends régulièrement l'urolithin de Mitopure , je ressens une plus grande énergie et mes muscles se renforcent . Excellent produit donc , que je recommande .
Optimistic
It's only been a week so far, but I do feel like my recovery from workouts has improved! I certainly will keep on taking them
Enjoying my later years!
Mitopure takes away the effort of doing my exercises. It gives more confidence as I go through my day because stress has become non existent. I am really glad to not feel old anymore.
Easy ordering and great costumer service
The ordering process was easy and just started taking.
Just start
Just start
Good product definitely feel better
I just started taking this product a couple weeks ago but I feel that I can do more weight training and don’t give up so easily. We’ll see in another month or so
Too early to experience...
Too early to experience any improvement. Give me a month to review.
Giving it a go!
I just recently received this product and so far so good.
Exercise Recovery
A bit early to evaluate but exercise recovery appears to be improving.
No reviews match these filters.
Frequently asked questions
Product information supplied by Timeline.
What is Timeline and Mitopure?
Mitopure (Urolithin A) is the active proprietary ingredient inside Timeline products. This novel postbiotic nutrient is clinically proven to boost cellular energy and muscle health by renewing mitochondria*.
Why is it important?
Muscle function starts to decline in our 30s as our mitochondria - our cellular powerhouses - start to break down and lose their efficiency. Mitopure is important because it activates a potent cellular recycling and renewal mechanism called mitophagy. This process cleans up defective mitochondria and allows the mitochondria to repair itself and improve its performance.
Who should take it?
Timeline is intended for healthy adults, ages 18 and up.
What is the recommended dosage?
For optimal benefits, based on clinical trials, we recommend 500mg of Mitopure per day for a minimum of 4 months to support mitochondrial health and muscle function.
What is our story?
Timeline and Mitopure are the product of more than 15 years of rigorous research and development by the innovative Swiss health science company Amazentis which is comprised of world-class scientists, physicians and product development professionals.
Ordering & support
Is this a subscription?
No. The packages on this page are one-time purchases.
How can I contact you?
Please use our Contact Us page.
Which packages are available?
Choose Buy 1, Get 1 Free; Buy 2, Get 2 Free; or Buy 3, Get 3 Free in the purchase section above.
Where can I find shipping information?
Please see our Shipping Policy for this store’s shipping information.
Where can I find return information?
Please see our Refund Policy for this store’s return information.